Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The genomic landscape of canine osteosarcoma cell lines reveals conserved structural complexity and pathway alterations

13 Sept 2022

Abstract excerpt

The characterization of immortalized canine osteosarcoma (OS) cell lines used for research has historically been based on phenotypic features such as cellular morphology and expression of bone specific markers. With the increasing use of these cell lines to investigate novel therapeutic approaches prior to in vivo translation, a much more detailed understanding regarding the genomic landscape of these lines is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Infectious Diseases and Mycology
Share to Veterinary Oncology Research
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36099278
DOI: 10.1371/journal.pone.0274383

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The genomic landscape of canine osteosarcoma cell lines reveals conserved structural complexity and pathway alterationsPMID 36099278Read ↗

Canine osteosarcoma genome sequencing identifies recurrent mutations in DMD and the histone methyltransferase gene SETD2Semantic proximity Read ↗

SETD2 Is Recurrently Mutated in Whole-Exome Sequenced Canine Osteosarcoma.Semantic proximity Read ↗

Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B.Semantic proximity Read ↗

Canine tumor mutational burden is correlated with TP53 mutation across tumor types and breeds.Semantic proximity Read ↗

Unraveling the chaotic genomic landscape of primary and metastatic canine appendicular osteosarcoma with current sequencing technologies and bioinformatic approaches.Semantic proximity Read ↗

Patient Derived Xenografts for Genome-Driven Therapy of OsteosarcomaSemantic proximity Read ↗

Canine Osteosarcoma: A Naturally Occurring Disease to Inform Pediatric OncologySemantic proximity Read ↗

Genomic analysis across 53 canine cancer types reveals novel mutations and high clinical actionability potential.Semantic proximity Read ↗

Establishment and characterization of three canine ameloblastoma cell lines with genomic and transcriptomic profiles.Semantic proximity Read ↗

Canine tumor mutation rate is positively correlated with TP53 mutation across cancer types and breedsSemantic proximity Read ↗

Analyses of canine cancer mutations and treatment outcomes using real-world clinico-genomics data of 2119 dogsSemantic proximity Read ↗

Multi-omic Longitudinal Analysis of Canine Osteosarcoma Identifies Inter-Patient Heterogeneity and Immune Enrichment in Metastatic LesionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.