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Article

Id4 dependent acetylation restores mutant-p53 transcriptional activity.

Molecular cancer - 13 Dec 2013

Knowell Ashley E, Patel Divya, Morton Derrick J, Sharma Pankaj, Glymph Shanora, Chaudhary Jaideep

Abstract excerpt

BACKGROUND: The mechanisms that can restore biological activity of mutant p53 are an area of high interest given that mutant p53 expression is observed in one third of prostate cancer. Here we demonstrate that Id4, an HLH transcriptional regulator and a tumor suppressor, can restore the mutant p53 transcriptional activity in prostate cancer cells. METHODS: Id4 was over-expressed in prostate cancer cell line DU145...

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Share to Acetylation
Share to Apoptosis
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

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Share to p300-CBP Transcription Factors

Share to Prostatic Neoplasms

Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 24330748
DOI: 10.1186/1476-4598-12-161
PMCID: PMC3866570

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BAX

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