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Article

Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases.

Molecular cell - 1 Dec 2001

Barlev N A, Liu L, Chehab N H, Mansfield K, Harris K G, Halazonetis T D, Berger S L

Abstract excerpt

Cellular DNA damage causes stabilization and activation of the tumor suppressor and transcription factor p53, in part by promoting multiple covalent modifications of the p53 protein, including acetylation. We investigated the importance of acetylation in p53 function and the mechanism by which acetylation influences p53 activity. Acetylation site substitutions reduced p53-dependent transcriptional induction and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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PMID: 11779500
DOI: 10.1016/s1097-2765(01)00414-2

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TRRAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases.PMID 11779500Read ↗

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