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Article

Intrinsic ubiquitination activity of PCAF controls the stability of the oncoprotein Hdm2.

Nature cell biology - 1 Mar 2007

Linares Laëtitia K, Kiernan Rosemary, Triboulet Robinson, Chable-Bessia Christine, Latreille Daniel, Cuvier Olivier, Lacroix Matthieu, Le Cam Laurent, Coux Olivier, Benkirane Monsef

Abstract excerpt

The p300-CBP-associated factor (PCAF) is a histone acetyltransferase (HAT) involved in the reversible acetylation of various transcriptional regulators, including the tumour suppressor p53. It is implicated in many cellular processes, such as transcription, differentiation, proliferation and apoptosis. We observed that knockdown of PCAF expression in HeLa or U2OS cell lines induces stabilization of the...

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Share to Proto-Oncogene Proteins c-bcl-2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 17293853
DOI: 10.1038/ncb1545

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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