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Article

Restoration of DNA-binding and growth-suppressive activity of mutant forms of p53 via a PCAF-mediated acetylation pathway.

Journal of cellular physiology - 1 Nov 2010

Perez Ricardo E, Knights Chad D, Sahu Geetaram, Catania Jason, Kolukula Vamsi K, Stoler Daniel, Graessmann Adolf, Ogryzko Vasily, Pishvaian Michael, Albanese Christopher, Avantaggiati Maria Laura

Abstract excerpt

Tumor-derived mutant forms of p53 compromise its DNA binding, transcriptional, and growth regulatory activity in a manner that is dependent upon the cell-type and the type of mutation. Given the high frequency of p53 mutations in human tumors, reactivation of the p53 pathway has been widely proposed as beneficial for cancer therapy. In support of this possibility p53 mutants possess a certain degree of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20589832
DOI: 10.1002/jcp.22285
PMCID: PMC3614009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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