Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p53 induces distinct epigenetic states at its direct target promoters.

BMC genomics - 15 Oct 2008

Vrba Lukas, Junk Damian J, Novak Petr, Futscher Bernard W

Abstract excerpt

BACKGROUND: The tumor suppressor protein p53 is a transcription factor that is mutated in many cancers. Regulation of gene expression by binding of wild-type p53 to its target sites is accompanied by changes in epigenetic marks like histone acetylation. We studied DNA binding and epigenetic changes induced by wild-type and mutant p53 in non-malignant hTERT-immortalized human mammary epithelial cells...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Chromatin Immunoprecipitation
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Human

Share to Histones

Share to Oligonucleotide Array Sequence Analysis

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 18922183
DOI: 10.1186/1471-2164-9-486
PMCID: PMC2585595

Genes

DGKZ
FBXO22
GDF9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p53 induces distinct epigenetic states at its direct target promoters.PMID 18922183Read ↗

Chromatin Immunoprecipitation-Based Screen To Identify Functional Genomic Binding Sites for Sequence-Specific TransactivatorsSemantic proximity Read ↗

Distinct p53 genomic binding patterns in normal and cancer-derived human cellsSemantic proximity Read ↗

Integrative genomic analysis reveals widespread enhancer regulation by p53 in response to DNA damageSemantic proximity Read ↗

Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cellsSemantic proximity Read ↗

Identification of direct p73 target genes combining DNA microarray and chromatin immunoprecipitation analyses.Semantic proximity Read ↗

p53motifDB: integration of genomic information and tumor suppressor p53 binding motifsSemantic proximity Read ↗

The common and distinct target genes of the p53 family transcription factorsSemantic proximity Read ↗

Identification of Novel p53 Target Genes in Ionizing Radiation ResponseSemantic proximity Read ↗

Mutant p53 is a transcriptional co-factor that binds to G-rich regulatory regions of active genes and generates transcriptional plasticity.Semantic proximity Read ↗

Interactions of mutant p53 with DNA: guilt by association.Semantic proximity Read ↗

Analysis of the DNA-binding activity of p53 mutants using functional protein microarrays and its relationship to transcriptional activation.Semantic proximity Read ↗

Mutant p53 regulates a distinct gene set by a mode of genome occupancy that is shared with wild type.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.