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Article

ID4: a new player in the cancer arena

1 May 2010

Abstract excerpt

Id proteins (Id-1 to 4) are dominant negative regulators of basic helix-loop-helix transcription factors. They play a key role during development, preventing cell differentiation while inducing cell proliferation. They are poorly expressed in adult life but can be reactivated in tumorigenesis. Several evidences indicate that Id proteins are associated with loss of differentiation, unrestricted proliferation and...

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PMID: 21293053
DOI: 10.18632/oncotarget.108

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