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Article

The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis.

Nature structural & molecular biology - 1 Oct 2009

Fontemaggi Giulia, Dell'Orso Stefania, Trisciuoglio Daniela, Shay Tal, Melucci Elisa, Fazi Francesco, Terrenato Irene, Mottolese Marcella, Muti Paola, Domany Eytan, Del Bufalo Donatella, Strano Sabrina, Blandino Giovanni

Abstract excerpt

ID4 (inhibitor of DNA binding 4) is a member of a family of proteins that function as dominant-negative regulators of basic helix-loop-helix transcription factors. Growing evidence links ID proteins to cell proliferation, differentiation and tumorigenesis. Here we identify ID4 as a transcriptional target of gain-of-function p53 mutants R175H, R273H and R280K. Depletion of mutant p53 protein severely impairs ID4...

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Identifiers

PMID: 19783986
DOI: 10.1038/nsmb.1669

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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