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Article

The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis.

Nature structural & molecular biology - 1 Oct 2009

Fontemaggi Giulia, Dell'Orso Stefania, Trisciuoglio Daniela, Shay Tal, Melucci Elisa, Fazi Francesco, Terrenato Irene, Mottolese Marcella, Muti Paola, Domany Eytan, Del Bufalo Donatella, Strano Sabrina, Blandino Giovanni

Abstract excerpt

ID4 (inhibitor of DNA binding 4) is a member of a family of proteins that function as dominant-negative regulators of basic helix-loop-helix transcription factors. Growing evidence links ID proteins to cell proliferation, differentiation and tumorigenesis. Here we identify ID4 as a transcriptiona...

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Source

Identifiers

PMID: 19783986
DOI: 10.1038/nsmb.1669

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19783986-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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