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Article

Inhibition of p53 degradation by Mdm2 acetylation.

FEBS letters - 12 Mar 2004

Wang Xinjiang, Taplick Jan, Geva Naama, Oren Moshe

Abstract excerpt

Mdm2 is a RING finger E3 ubiquitin ligase, which promotes ubiquitination and proteasomal degradation of the p53 tumor suppressor protein. Acetylation of p53 regulates p53's transcriptional activity and inhibits Mdm2-mediated p53 ubiquitination and degradation. We now report that Mdm2 is also a target for acetylation. Mdm2 is acetylated in vitro by CREB-binding protein (CBP) and to a lesser extent by p300, but not...

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Identifiers

PMID: 15013777
DOI: 10.1016/S0014-5793(04)00168-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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