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Article

ROCK1 isoform-specific deletion reveals a role for diet-induced insulin resistance

11 Dec 2013

Abstract excerpt

Rho kinase (ROCK) isoforms regulate insulin signaling and glucose metabolism negatively or positively in cultured cell lines and skeletal muscle. However, the in vivo function of the ROCK1 isoform in adipose tissue has not been addressed. To determine the specific role of the adipose ROCK1 isoform in the development of insulin resistance and obesity, mice lacking ROCK1 in adipose tissue globally or selectively...

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PMID: 24326423
DOI: 10.1152/ajpendo.00619.2013

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