Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rho-kinase inhibition ameliorates metabolic disorders through activation of AMPK pathway in mice.

PloS one - 1 Jan 2014

Noda Kazuki, Nakajima Sota, Godo Shigeo, Saito Hiroki, Ikeda Shohei, Shimizu Toru, Enkhjargal Budbazar, Fukumoto Yoshihiro, Tsukita Sohei, Yamada Tetsuya, Katagiri Hideki, Shimokawa Hiroaki

Abstract excerpt

BACKGROUND: Metabolic disorders, caused by excessive calorie intake and low physical activity, are important cardiovascular risk factors. Rho-kinase, an effector protein of the small GTP-binding protein RhoA, is an important cardiovascular therapeutic target and its activity is increased in patients with metabolic syndrome. We aimed to examine whether Rho-kinase inhibition improves high-fat diet (HFD)-induced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AMP-Activated Protein Kinases
Share to Diet, High-Fat

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Energy Metabolism

Share to Enzyme Activation

Share to Metabolic Diseases

Share to Muscle, Skeletal

Share to Protein Kinase Inhibitors

Share to rho-Associated Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 25365359
DOI: 10.1371/journal.pone.0110446
PMCID: PMC4217731

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rho-kinase inhibition ameliorates metabolic disorders through activation of AMPK pathway in mice.PMID 25365359Read ↗

Rho and Rho-kinase activity in adipocytes contributes to a vicious cycle in obesity that may involve mechanical stretch.Semantic proximity Read ↗

Insight Into Rho Kinase Isoforms in Obesity and Energy HomeostasisSemantic proximity Read ↗

AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation.Semantic proximity Read ↗

AMPK, insulin resistance, and the metabolic syndromeSemantic proximity Read ↗

Hepatocyte Rap1a Contributes To Obesity- and Statin-Associated HyperglycemiaSemantic proximity Read ↗

Rap1 Activation Protects Against Fatty Liver and Non-Alcoholic Steatohepatitis DevelopmentSemantic proximity Read ↗

ROCK1 isoform-specific deletion reveals a role for diet-induced insulin resistanceSemantic proximity Read ↗

AMPK promotes tolerance to Ras pathway inhibition by activating autophagySemantic proximity Read ↗

Crucial role for LKB1 to AMPKalpha2 axis in the regulation of CD36-mediated long-chain fatty acid uptake into cardiomyocytes.Semantic proximity Read ↗

Sexual Dimorphism in Cardiometabolic Diseases: The Role of AMPKSemantic proximity Read ↗

Aerobic exercise improves hepatic steatosis by modulating miR-34a-mediated PPARα/SIRT1-AMPK signaling pathwaySemantic proximity Read ↗

Role of AMP-activated protein kinase in the metabolic syndrome and in heart disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.