Article
Lack of interleukin-1 receptor I (IL-1RI) protects mice from high-fat diet-induced adipose tissue inflammation coincident with improved glucose homeostasis.
Diabetes - 1 Jun 2011
McGillicuddy Fiona C, Harford Karen A, Reynolds Clare M, Oliver Elizabeth, Claessens Mandy, Mills Kingston H G, Roche Helen M
Abstract excerpt
OBJECTIVE: High-fat diet (HFD)-induced adipose tissue inflammation is a critical feature of diet-induced insulin resistance (IR); however, the contribution of interleukin-1 receptor I (IL-1RI)-mediated signals to this phenotype has not been defined. We hypothesized that lack of IL-1RI may ameliorate HFD-induced IR by attenuating adipose tissue inflammation. RESEARCH DESIGN AND METHODS: Glucose homeostasis was...
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