Article
Network analysis of adipose tissue gene expression highlights altered metabolic and regulatory transcriptomic activity in high-fat-diet-fed IL-1RI knockout mice.
The Journal of nutritional biochemistry - 1 May 2013
Morine Melissa J, Toomey Sinead, McGillicuddy Fiona C, Reynolds Clare M, Power Karen A, Browne John A, Loscher Christine, Mills Kingston H G, Roche Helen M
Abstract excerpt
A subacute inflammatory phenotype is implicated in the pathology of insulin resistance (IR) and type 2 diabetes mellitus. Interleukin (IL)-1α and IL-1β are produced by innate immune cells, including macrophages, and mediate their inflammatory response through the IL-1 type I receptor (IL-IRI). This study sought to understand the transcriptomic signature of adipose tissue in obese IL-1RI(-/-) mice. Following...
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