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Article

Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism.

Skeletal muscle - 1 Jan 2016

Guridi Maitea, Kupr Barbara, Romanino Klaas, Lin Shuo, Falcetta Denis, Tintignac Lionel, Rüegg Markus A

Abstract excerpt

BACKGROUND: The mammalian target of rapamycin complex 1 (mTORC1) is a central node in a network of signaling pathways controlling cell growth and survival. This multiprotein complex integrates external signals and affects different nutrient pathways in various organs. However, it is not clear how alterations of mTORC1 signaling in skeletal muscle affect whole-body metabolism. RESULTS: We characterized the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27004103
DOI: 10.1186/s13395-016-0084-8
PMCID: PMC4800774

Genes

TSC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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