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Article

Constitutive adipocyte mTORC1 activation enhances mitochondrial activity and reduces visceral adiposity in mice.

Biochimica et biophysica acta - 1 May 2016

Magdalon Juliana, Chimin Patricia, Belchior Thiago, Neves Rodrigo X, Vieira-Lara Marcel A, Andrade Maynara L, Farias Talita S, Bolsoni-Lopes Andressa, Paschoal Vivian A, Yamashita Alex S, Kowaltowski Alicia J, Festuccia William T

Abstract excerpt

Mechanistic target of rapamycin complex 1 (mTORC1) loss of function reduces adiposity whereas partial mTORC1 inhibition enhances fat deposition. Herein we evaluated how constitutive mTORC1 activation in adipocytes modulates adiposity in vivo. Mice with constitutive mTORC1 activation in adipocytes induced by tuberous sclerosis complex (Tsc)1 deletion and littermate controls were evaluated for body mass, energy...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26923434
DOI: 10.1016/j.bbalip.2016.02.023

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PGC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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