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Article

Toll-like receptor polymorphism associations with HIV-1 outcomes among sub-Saharan Africans.

The Journal of infectious diseases - 15 May 2014

Mackelprang Romel D, Bigham Abigail W, Celum Connie, de Bruyn Guy, Beima-Sofie Kristin, John-Stewart Grace, Ronald Allan, Mugo Nelly R, Buckingham Kati J, Bamshad Michael J, Mullins James I, McElrath M Juliana, Lingappa Jairam R

Abstract excerpt

OBJECTIVE: We evaluated Toll-like receptors (TLRs) single nucleotide polymorphisms (SNPs) for associations with HIV-1 acquisition, set-point and disease progression in African couples. METHODS: Seven candidate and 116 haplotype-tagging SNPs (tagSNPs) were genotyped in 504 HIV-1 infected cases, and 343 seronegative controls. RESULTS: TLR9 1635A/G was associated with reduced HIV-1 acquisition among HIV-seronegative...

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Share to Africa South of the Sahara
Share to Anti-HIV Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Infections

Share to RNA, Viral

Share to Toll-Like Receptors

Share to Viral Load

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 24325963
DOI: 10.1093/infdis/jit807
PMCID: PMC3997584

Genes

TLR2
TLR7
TLR8
TLR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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