Article
Africa-specific human genetic variation near CHD1L associates with HIV-1 load.
Nature - 1 Aug 2023
McLaren Paul J, Porreca Immacolata, Iaconis Gennaro, Mok Hoi Ping, Mukhopadhyay Subhankar, Karakoc Emre, Cristinelli Sara, Pomilla Cristina, Bartha István, Thorball Christian W, Tough Riley H, Angelino Paolo, Kiar Cher S, Carstensen Tommy, Fatumo Segun, Porter Tarryn, Jarvis Isobel, Skarnes William C, Bassett Andrew, DeGorter Marianne K, Sathya Moorthy Mohana Prasad, Tuff Jeffrey F, Kim Eun-Young, Walter Miriam, Simons Lacy M, Bashirova Arman, Buchbinder Susan, Carrington Mary, Cossarizza Andrea, De Luca Andrea, Goedert James J, Goldstein David B, Haas David W, Herbeck Joshua T, Johnson Eric O, Kaleebu Pontiano, Kilembe William, Kirk Gregory D, Kootstra Neeltje A, Kral Alex H, Lambotte Olivier, Luo Ma, Mallal Simon, Martinez-Picado Javier, Meyer Laurence, Miro José M, Moodley Pravi, Motala Ayesha A, Mullins James I, Nam Kireem, Obel Niels, Pirie Fraser, Plummer Francis A, Poli Guido, Price Matthew A, Rauch Andri, Theodorou Ioannis, Trkola Alexandra, Walker Bruce D, Winkler Cheryl A, Zagury Jean-François, Montgomery Stephen B, Ciuffi Angela, Hultquist Judd F, Wolinsky Steven M, Dougan Gordon, Lever Andrew M L, Gurdasani Deepti, Groom Harriet, Sandhu Manjinder S, Fellay Jacques
Abstract excerpt
HIV-1 remains a global health crisis1, highlighting the need to identify new targets for therapies. Here, given the disproportionate HIV-1 burden and marked human genome diversity in Africa2, we assessed the genetic determinants of control of set-point viral load in 3,879 people of African ancestries living with HIV-1 participating in the international collaboration for the genomics of HIV3. We identify a...
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