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Article

Toll-like receptor variants are associated with infant HIV-1 acquisition and peak plasma HIV-1 RNA level.

AIDS (London, England) - 24 Sept 2013

Beima-Sofie Kristin M, Bigham Abigail W, Lingappa Jairam R, Wamalwa Dalton, Mackelprang Romel D, Bamshad Michael J, Maleche-Obimbo Elizabeth, Richardson Barbra A, John-Stewart Grace C

Abstract excerpt

OBJECTIVE: We evaluated the association of single nucleotide polymorphisms (SNPs) in TLRs with infant HIV-1 acquisition and viral control. DESIGN: Infant HIV-1 outcomes were assessed in a Kenyan perinatal HIV-1 cohort. METHODS: Infants were genotyped for six candidate and 118 haplotype-tagging polymorphisms in TLRs 2, 3, 4, 7, 8, and 9, MYD88 and TIRAP. Cox proportional hazards and linear regression were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24037211
DOI: 10.1097/QAD.0b013e3283629117
PMCID: PMC4124859

Genes

TLR9
MYD88
TIRAP
TLR7
TLR8

Provenance

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