Article
Polymorphisms in Toll-like receptor 9 influence the clinical course of HIV-1 infection.
AIDS (London, England) - 19 Feb 2007
Bochud Pierre-Yves, Hersberger Martin, Taffé Patrick, Bochud Murielle, Stein Catherine M, Rodrigues Stephanie D, Calandra Thierry, Francioli Patrick, Telenti Amalio, Speck Roberto F, Aderem Alan
Abstract excerpt
BACKGROUND: The clinical course of HIV-1 infection is highly variable among individuals, at least in part as a result of genetic polymorphisms in the host. Toll-like receptors (TLRs) have a key role in innate immunity and mutations in the genes encoding these receptors have been associated with increased or decreased susceptibility to infections. OBJECTIVES: To determine whether single-nucleotide polymorphisms...
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