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An assessment of toll-like receptor 7 and 8 gene polymorphisms with susceptibility to HIV-1 infection, AIDS development and response to antiretroviral therapy.

Immunology letters - 1 Nov 2020

Zaidane Imane, Ouladlahsen Ahd, Bensghir Rajaa, Chihab Hajar, Jadid Fatima Zahra, Fɩhry Raouia El, Baba Hanâ, Filali Kamal Marhoum El, Oudghiri Mounia, Wakrim Lahcen, Benjelloun Soumaya, Ezzikouri Sayeh

Abstract excerpt

Toll-like receptors (TLRs) play an important role in activating the innate immune response, inducing inflammation and initiating the adaptive immune response. In this study, we assess the influence of TLR7 and TLR8 gene polymorphisms on HIV-1 susceptibility, AIDS development, and treatment outcomes. The TLR7 and TLR8 single nucleotide polymorphisms (SNPs) were genotyped through real-time PCR in 222 patients...

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PMID: 32888973
DOI: 10.1016/j.imlet.2020.08.008

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