Article
Toll-like receptor 9 polymorphisms influence mother-to-child transmission of human immunodeficiency virus type 1.
Journal of translational medicine - 25 May 2010
Ricci Elisabetta, Malacrida Sandro, Zanchetta Marisa, Mosconi Ilaria, Montagna Marco, Giaquinto Carlo, De Rossi Anita
Abstract excerpt
BACKGROUND: Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns and play a crucial role in the host's innate immune response. Genetic variations in TLR genes may influence host-viral interactions and might impact upon the risk of mother-to-child transmission (MTCT) of Human Immunodeficiency Virus type 1 (HIV-1). The aim of this study was to investigate the influence of genetic variants of...
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