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Article

A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joining

1 Sept 2016

Abstract excerpt

Loss of p53, a transcription factor activated by cellular stress, is a frequent event in cancer. The role of p53 in tumour suppression is largely attributed to cell fate decisions. Here, we provide evidence supporting a novel role for p53 in the regulation of DNA double-strand break (DSB) repair pathway choice. 53BP1, another tumour suppressor, was initially identified as p53 Binding Protein 1, and has been shown...

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PMID: 27655732
DOI: 10.1098/rsob.160225

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A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joiningPMID 27655732Read ↗

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