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Article

Repair Pathway Choices and Consequences at the Double-Strand Break.

Trends in cell biology - 1 Jan 2016

Ceccaldi Raphael, Rondinelli Beatrice, D'Andrea Alan D

Abstract excerpt

DNA double-strand breaks (DSBs) are cytotoxic lesions that threaten genomic integrity. Failure to repair a DSB has deleterious consequences, including genomic instability and cell death. Indeed, misrepair of DSBs can lead to inappropriate end-joining events, which commonly underlie oncogenic transformation due to chromosomal translocations. Typically, cells employ two main mechanisms to repair DSBs: homologous...

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Identifiers

PMID: 26437586
DOI: 10.1016/j.tcb.2015.07.009
PMCID: PMC4862604

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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