Article
Frequency and genotype distribution of ABCB1 gene polymorphisms among Maharashtrian population of Central India.
Xenobiotica; the fate of foreign compounds in biological systems - 1 Jun 2014
Pramanik Sreemanta, Surendran Subin T, Devi Saravana, Krishnamurthi Kannan, Chakrabarti Tapan
Abstract excerpt
1. Apart from conferring multidrug resistance to cancer cells, P-glycoprotein (P-gp) encoded by the gene ABCB1 (also, known as Multidrug resistance gene, MDR1), plays a major role in drug disposition. Single nucleotide polymorphisms (SNPs) in the ABCB1 gene might contribute to inter-individual and ethnic differences in drug disposition and thereby, could influence the outcome and prognosis of certain diseases....
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