Article
Inter and intra-ethnic differences in the distribution of the molecular variants of TPMT, UGT1A1 and MDR1 genes in the South Indian population.
Molecular biology reports - 1 May 2012
Umamaheswaran Gurusamy, Krishna Kumar Dhakchinamoorthi, Kayathiri Dhandapani, Rajan Subramanian, Shewade Deepak Gopal, Dkhar Steven Aibor, Manjunath Sajjanavar, Ushakiran Prayaga, Reneega Gangadharan, Ritushree Kukreti, Adithan Chandrasekaran
Abstract excerpt
Molecular variants of polymorphic drug metabolizing enzymes and drug transporters are attributed to differences in individual's therapeutic response and drug toxicity in different populations. We sought to determine the genotype and allele frequencies of polymorphisms for major phase II drug-metabolizing enzymes (TPMT, UGT1A1) and drug transporter (MDR1) in South Indians. Allelic variants of TPMT (*2,*3A,*3B,*3C...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.