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Article

Clinical aspects of the MDR1 (ABCB1) gene polymorphism.

Therapeutic drug monitoring - 1 Apr 2004

Eichelbaum Michel, Fromm Martin F, Schwab Matthias

Abstract excerpt

Transporter proteins, in particular P-glycoprotein (Pgp), are important determinants in absorption, tissue targeting, and elimination of drugs. In addition to physiological and environmental factors, its expression and function are modified by genetic polymorphisms of the MDR1 gene. So far, several MDR1 SNPs have been identified, and mutations at positions 2677 and 3435 were associated with alteration of Pgp...

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Share to Abnormalities, Drug-Induced
Share to Antidepressive Agents, Tricyclic
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15228162
DOI: 10.1097/00007691-200404000-00017

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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