Article
Polymorphic variation of CYP1A1 and CYP1B1 genes in a Haryana population.
Biochemical genetics - 1 Dec 2013
Giri Shiv Kumar, Yadav Anita, Kumar Anil, Dev Kapil, Gulati Sachin, Gupta Ranjan, Aggarwal Neeraj, Gautam Sanjeev Kumar
Abstract excerpt
Cytochrome P450 (CYP) 1A1 and CYP1B1 are important phase I xenobiotic metabolizing enzymes involved in the metabolism of numbers of toxins, endogenous hormones, and pharmaceutical drugs. Polymorphisms in these phase I genes can alter enzyme activity and are known to be associated with cancer susceptibility related to environmental toxins and hormone exposure. Their genotypes may also display ethnicity-dependent...
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