Article
ABCB1 single nucleotide polymorphisms in the Brazilian population.
Molecular biology reports - 1 Jan 2010
Scheiner Marcos Antonio Mauricio, Damasceno Arthur Motta, Maia Raquel Ciuvalschi
Abstract excerpt
The ABCB1/MDR-1 gene, which encodes P-glycoprotein, is highly polymorphic. We analyzed 278 healthy Brazilian individuals through PCR-RFLP to identify ABCB1 variants and determine the genotypic and allelic frequencies. Genotypic frequencies for C1236T (rs1128503) were 0.31 for CC, 0.60 for CT and 0.09 for TT and allelic frequencies were 0.61 and 0.39 for C and T, respectively. Genotypic frequencies for C3435T...
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