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Article

Structural and energetic analyses of SNPs in drug targets and implications for drug therapy.

Journal of chemical information and modeling - 23 Dec 2013

Sun Hui-Yong, Ji Feng-Qin, Fu Liang-Yu, Wang Zhong-Yi, Zhang Hong-Yu

Abstract excerpt

Mutations in drug targets can alter the therapeutic effects of drugs. Therefore, evaluating the effects of single-nucleotide polymorphisms (SNPs) on drug-target binding is of significant interest. This study focuses on the analysis of the structural and energy properties of SNPs in successful drug targets by using the data derived from HapMap and the Therapeutic Target Database. The results show the following:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24304102
DOI: 10.1021/ci400457v

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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