Article
Emerging new technologies in Pharmacogenomics: rapid SNP detection, molecular dynamic simulation, and QSAR analysis methods to validate clinically important genetic variants of human ABC Transporter ABCB1 (P-gp/MDR1).
Pharmacology & therapeutics - 1 Apr 2010
Ishikawa Toshihisa, Sakurai Aki, Hirano Hiroyuki, Lezhava Alexander, Sakurai Minoru, Hayashizaki Yoshihide
Abstract excerpt
Pharmacogenomics, the study of the influence of genetic factors on drug action, is increasingly important for predicting pharmacokinetics profiles and/or adverse reactions to drugs. Drug transporters as well as drug-metabolism play pivotal roles in determining the pharmacokinetic profiles of drug...
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