Article

Impact of peripheral mutations on the access channels of human cytochrome P450 1A2

2019-09-03

Abstract excerpt

As an important member of cytochrome P450 (CYP) enzymes, human CYP1A2 is associated with the metabolism of caffeine and melatonin and the activation of precarcinogens. Besides, this CYP protein also involves in metabolizing 5-10% of clinical medicines. Some peripheral mutations in CYP1A2 (P42R, I386F, R431W, and R456H) significantly decrease the enzyme activities, resulting in a vital reduction in substrate metabo...

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Literature Corpus work: d082248b-5822-517f-a3b0-e7b819cb6955
DOI: 10.1101/754739

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