Article
In silico SNP analysis and bioinformatics tools: a review of the state of the art to aid drug discovery.
Drug discovery today - 1 Sept 2011
Mah James T L, Low Esther S H, Lee Edmund
Abstract excerpt
SNPs can alter protein function and phenotype, leading to altered pharmacogenomic drug profiles. The exponential number of SNPs makes it impossible to perform wet laboratory experiments to determine the biological significance of each one. However, bioinformatics tools can be used to screen for potentially deleterious SNPs that might affect important drug targets before further investigation by wet laboratory...
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