Article
Molecular Basis of Bicalutamide Response Alteration of Androgen Receptor Caused by Single Nucleotide Polymorphisms: An In Silico Investigation.
Critical reviews in eukaryotic gene expression - 1 Jan 2019
Hadian Noushin, Farsani Farzaneh Mohamadi, Ganjalikhany Mohamad Reza, Sazegar Hossein, Sadeghi Mehdi
Abstract excerpt
The vast majority of drugs act through binding to their protein targets. Prediction of the interaction between small molecules and these receptors is a key element in the process of drug discovery. Advances in structural biology have enabled us to resolve the three-dimensional structure of proteins, which are the targets of the drugs. Pharmacogenetics also helped researchers to study the structural variations...
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