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Article

Molecular modeling of two CYP2C19 SNPs and its implications for personalized drug design.

Protein and peptide letters - 1 Jan 2008

Wang Jing-Fang, Wei Dong-Qing, Chen Chao, Li Yixue, Chou Kuo-Chen

Abstract excerpt

CYP2C19 is an important member of the cytochrome P-450 enzyme superfamily and plays a significant role in the drug metabolism. In order to gain insights for developing personalized drugs, the structure-activity relationships of two SNPs, W120R and I331V, with the ligands of CEC, Fluvoxamine, Lescol and Ticlopidine were investigated through the structure-activity relationship approach. By means of a series of...

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Source

Identifiers

PMID: 18221009
DOI: 10.2174/092986608783330305

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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