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Article

Loss of Miro1-directed mitochondrial movement results in a novel murine model for neuron disease.

Proceedings of the National Academy of Sciences of the United States of America - 2 Sept 2014

Nguyen Tammy T, Oh Sang S, Weaver David, Lewandowska Agnieszka, Maxfield Dane, Schuler Max-Hinderk, Smith Nathan K, Macfarlane Jane, Saunders Gerald, Palmer Cheryl A, Debattisti Valentina, Koshiba Takumi, Pulst Stefan, Feldman Eva L, Hajnóczky György, Shaw Janet M

Abstract excerpt

Defective mitochondrial distribution in neurons is proposed to cause ATP depletion and calcium-buffering deficiencies that compromise cell function. However, it is unclear whether aberrant mitochondrial motility and distribution alone are sufficient to cause neurological disease. Calcium-binding mitochondrial Rho (Miro) GTPases attach mitochondria to motor proteins for anterograde and retrograde transport in...

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PMID: 25136135
DOI: 10.1073/pnas.1402449111
PMCID: PMC4156725

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