Article

Mitochondrial turnover at central GABAergic synapses governs vulnerability to epileptic seizures

2026-06-28

Abstract excerpt

<h4>Summary</h4> Mitochondrial dysfunction has long been known to underlie neurodegeneration, yet the contribution of mitochondrial turnover dynamics to functional aspects of defined synaptic circuits remains poorly understood. Here, we show that the mitochondrial proteome and turnover rates of hippocampal glutamatergic and GABAergic neurons is differentially remodelled by experience, with distal axon terminals o...

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Literature Corpus work: c15ff39d-381b-542a-b6c0-dc0a0c1edf9e
DOI: 10.64898/2026.06.24.734182

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