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Article

Miro1-dependent mitochondrial dynamics in parvalbumin interneurons.

eLife - 30 Jun 2021

Kontou Georgina, Antonoudiou Pantelis, Podpolny Marina, Szulc Blanka R, Arancibia-Carcamo I Lorena, Higgs Nathalie F, Lopez-Domenech Guillermo, Salinas Patricia C, Mann Edward O, Kittler Josef T

Abstract excerpt

The spatiotemporal distribution of mitochondria is crucial for precise ATP provision and calcium buffering required to support neuronal signaling. Fast-spiking GABAergic interneurons expressing parvalbumin (PV+) have a high mitochondrial content reflecting their large energy utilization. The importance for correct trafficking and precise mitochondrial positioning remains poorly elucidated in inhibitory neurons....

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Identifiers

PMID: 34190042
DOI: 10.7554/eLife.65215
PMCID: PMC8294849

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