JIP3 mediates TrkB axonal anterograde transport and enhances BDNF signaling by directly bridging TrkB with kinesin-1.

doi:10.1523/JNEUROSCI.0436-11.2011

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Article

JIP3 mediates TrkB axonal anterograde transport and enhances BDNF signaling by directly bridging TrkB with kinesin-1.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 20 Jul 2011

Huang Shu-Hong, Duan Shan, Sun Tao, Wang Jue, Zhao Ling, Geng Zhao, Yan Jing, Sun Hai-Ji, Chen Zhe-Yu

Abstract excerpt

Brain-derived neurotrophic factor (BDNF), secreted from target tissues, binds and activates TrkB receptors, located on axonal terminals of the innervating neurons, and thereby initiates retrograde signaling. Long-range anterograde transport of TrkB in axons and dendrites requires kinesin-mediated transport. However, it remains unknown whether anterograde TrkB transport mechanisms are the same in axons versus in...

Topics

Adaptor Proteins, Signal Transducing
Analysis of Variance
Animals
Axonal Transport
Axons
Brain-Derived Neurotrophic Factor
Cell Line, Transformed
Hippocampus
Humans
Immunoprecipitation

Kinesins

Ligation

Luminescent Proteins

Male

Mice

Mice, Transgenic

Microtubule-Associated Proteins

Mutation

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