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Article

JIP3 mediates TrkB axonal anterograde transport and enhances BDNF signaling by directly bridging TrkB with kinesin-1.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 20 Jul 2011

Huang Shu-Hong, Duan Shan, Sun Tao, Wang Jue, Zhao Ling, Geng Zhao, Yan Jing, Sun Hai-Ji, Chen Zhe-Yu

Abstract excerpt

Brain-derived neurotrophic factor (BDNF), secreted from target tissues, binds and activates TrkB receptors, located on axonal terminals of the innervating neurons, and thereby initiates retrograde signaling. Long-range anterograde transport of TrkB in axons and dendrites requires kinesin-mediated transport. However, it remains unknown whether anterograde TrkB transport mechanisms are the same in axons versus in...

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Identifiers

PMID: 21775604
DOI: 10.1523/JNEUROSCI.0436-11.2011
PMCID: PMC6622626

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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