Article

Neuronal Mitochondrial Dysfunction Drives Astrocytic Mitochondrial Transfer after TBI: Reveals the Therapeutic Potential of astrocytic EV-Mito

2026-07-06

Abstract excerpt

<title>Abstract</title> <p> Mitochondria are dynamic organelles essential for neuronal survival and synaptic function, and their dysfunction is a key consequence of excitotoxicity following traumatic brain injury (TBI). While intercellular mitochondrial transfer and exogenous mitochondrial transplantation have emerged as mechanisms to restore cellular bioenergetics, its <italic>in vivo</italic> relevance in th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1250e665-f1d3-5e64-bbd9-579dd0b52107
DOI: 10.21203/rs.3.rs-10105855/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Neuronal Mitochondrial Dysfunction Drives Astrocytic Mitochondrial Transfer after TBI: Reveals the Therapeutic Potential of astrocytic EV-MitoDOI 10.21203/rs.3.rs-10105855/v1Read

Mitochondrial transplantation improves bioenergetics and neurite outgrowth in disease-associated P301Ltau-expressing neuronal cellsSemantic proximity Read

Mitochondrial quality control and transfer communication in neurological disorders and neuroinflammationSemantic proximity Read

The Silent Saboteur: How Mitochondria Shape the Long-Term Fate of the Injured BrainSemantic proximity Read

The bioenergetics of traumatic brain injury and its long-term impact for brain plasticity and functionSemantic proximity Read

Mitochondrial Transfer from Astrocytes to Neurons following Ischemic Insult: Guilt by Association?Semantic proximity Read

Modeling Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes Syndrome Using Patient-Derived Induced Neurons Generated by Direct Reprogramming.Semantic proximity Read

UNDERSTANDING THE ROLE OF DYSFUNCTIONAL AND HEALTHY MITOCHONDRIA IN STROKE PATHOLOGY AND ITS TREATMENTSemantic proximity Read

Regenerative abilities of mesenchymal stem cells through mitochondrial transferSemantic proximity Read

Prospective Approach to Deciphering the Impact of Intercellular Mitochondrial Transfer from Human Neural Stem Cells and Brain Tumor-Initiating Cells to Neighboring AstrocytesSemantic proximity Read

Human neural stem cells derived from fetal human brain communicate each other and rescue ischemic neurons through tunneling nanotubesSemantic proximity Read

Microvesicles Transfer Mitochondria and Increase Mitochondrial Function in Brain Endothelial CellsSemantic proximity Read

Lineage-specific changes in mitochondrial properties during neural stem cell differentiationSemantic proximity Read