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Article

Genetic variants modify susceptibility to leukemia in infants: a Children's Oncology Group report.

Pediatric blood & cancer - 1 Jan 2013

Ross Julie A, Linabery Amy M, Blommer Crystal N, Langer Erica K, Spector Logan G, Hilden Joanne M, Heerema Nyla A, Radloff Gretchen A, Tower Richard L, Davies Stella M

Abstract excerpt

BACKGROUND: The mixed lineage leukemia (MLL) gene is commonly rearranged in infant leukemia (IL). Genetic determinants of susceptibility to IL are unknown. Recent genome-wide association studies for childhood acute lymphoblastic leukemia (ALL) have identified susceptibility loci at IKZF1, ARID5B, and CEBPE. PROCEDURE: We genotyped these loci in 171 infants with leukemia and 384 controls and evaluated associations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone-Lysine N-Methyltransferase

Share to Ikaros Transcription Factor

Share to Leukemia, Myeloid, Acute

Share to Myeloid-Lymphoid Leukemia Protein

Share to Polymorphism, Single Nucleotide

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Source

Open in PubMed Open full text

Identifiers

PMID: 22422485
DOI: 10.1002/pbc.24131
PMCID: PMC3381932

Genes

IKZF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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