Article
Prevalence, tumorigenic role, and biochemical implications of rare BRAF alterations.
Thyroid : official journal of the American Thyroid Association - 1 May 2014
Barollo Susi, Pezzani Raffaele, Cristiani Andrea, Redaelli Marco, Zambonin Laura, Rubin Beatrice, Bertazza Loris, Zane Mariangela, Mucignat-Caretta Carla, Bulfone Alessandro, Pennelli Gianmaria, Casal Ide Eric, Pelizzo Maria Rosa, Mantero Franco, Moro Stefano, Mian Caterina
Abstract excerpt
BACKGROUND: Papillary thyroid carcinoma (PTC) is the most common malignant tumor of the thyroid gland, accounting for 74-80% of all thyroid cancers. The 1799T>A transversion is an activating mutation of the BRAF oncogene that is common in and specific to conventional PTC. We studied the prevalence, tumorigenic role, and biochemical implications of rare BRAF variants in a large cohort of patients. METHODS: A total...
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