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Article

The role of BRAF in the pathogenesis of thyroid carcinoma.

Frontiers in bioscience (Landmark edition) - 1 Jun 2015

Li Dan-Dan, Zhang Yi-Feng, Xu Hui-Xiong, Zhang Xiao-Ping

Abstract excerpt

BRAF is a cytoplasmic serine-threonine protein kinasethat plays a critical role in the MAPK signaling pathway. BRAF is the only member of the RAF family activated by mutation in human cancers. A single amino acid substitution (V600E) accounts for a multitude of human cancers, which causes constitutive kinase activity. In papillary thyroid cancer (PTC) and papillary-derived anaplastic thyroid cancer (ATC), the...

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Source

Identifiers

PMID: 25961545
DOI: 10.2741/4359

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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