Article
BRAF mutation in papillary thyroid cancer: pathogenic role, molecular bases, and clinical implications.
Endocrine reviews - 1 Dec 2007
Xing Mingzhao
Abstract excerpt
In recent years, the T1799A B-type Raf kinase (BRAF) mutation in thyroid cancer has received enthusiastic investigation, and significant progress has been made toward understanding its tumorigenic role and clinical significance. Among various thyroid tumors, this mutation occurs uniquely in papillary thyroid cancer (PTC), the most common endocrine malignancy, and some apparently PTC-derived anaplastic thyroid...
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