Article
BRAF mutation in papillary thyroid carcinoma: pathogenic role and clinical implications.
Journal of the Chinese Medical Association : JCMA - 1 Mar 2010
Tang Kam-Tsun, Lee Chen-Hsen
Abstract excerpt
Papillary thyroid cancer (PTC) is the most common endocrine malignancy, accounting for 85-90% of all thyroid cancers. Genetic alternations involving the mitogen-activated protein kinase (MAPK) pathway are frequently demonstrated in PTC, such as RET/PTC, RAS, and B-type Raf kinase (BRAF) mutations. Over 90% of BRAF mutations are T1799A, resulting in a BRAF(V600E) mutation. BRAF(V600E) is present in approximately...
Topics
- Carcinoma, Papillary
- Humans
- Mutation
- Proto-Oncogene Proteins B-raf
- Thyroid Neoplasms