Article
Disrupted cross-laminar cortical processing in β amyloid pathology precedes cell death.
Neurobiology of disease - 1 Mar 2014
Lison H, Happel M F K, Schneider F, Baldauf K, Kerbstat S, Seelbinder B, Schneeberg J, Zappe M, Goldschmidt J, Budinger E, Schröder U H, Ohl F W, Schilling S, Demuth H-U, Scheich H, Reymann K G, Rönicke R
Abstract excerpt
Disruption of neuronal networks in the Alzheimer-afflicted brain is increasingly recognized as a key correlate of cognitive and memory decline in Alzheimer patients. We hypothesized that functional synaptic disconnections within cortical columnar microcircuits by pathological β-amyloid accumulation, rather than cell death, initially causes the cognitive impairments. During development of cortical β-amyloidosis...
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