Article

In vivo assay of cortical microcircuitry in frontotemporal dementia: a platform for experimental medicine studies

2018-09-13

Abstract excerpt

The analysis of neural circuits can provide critical insights into the mechanisms of neurodegeneration and dementias, and offer potential quantitative biological tools to assess novel therapeutics. Here we use behavioural variant frontotemporal dementia (bvFTD) as a model disease. We demonstrate that inversion of canonical microcircuit models to non-invasive human magnetoecphalography can identify the regional- an...

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Literature Corpus work: c81fa9fa-6cf5-5d60-8e92-5f86af94e6af
DOI: 10.1101/416388

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