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Article

Early hippocampal hyperexcitability in PS2APP mice: role of mutant PS2 and APP.

Neurobiology of aging - 1 Feb 2017

Fontana Roberto, Agostini Mario, Murana Emanuele, Mahmud Mufti, Scremin Elena, Rubega Maria, Sparacino Giovanni, Vassanelli Stefano, Fasolato Cristina

Abstract excerpt

Alterations of brain network activity are observable in Alzheimer's disease (AD) together with the occurrence of mild cognitive impairment, before overt pathology. However, in humans as well in AD mouse models, identification of early biomarkers of network dysfunction is still at its beginning. We performed in vivo recordings of local field potential activity in the dentate gyrus of PS2APP mice expressing the...

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Source

Identifiers

PMID: 27889678
DOI: 10.1016/j.neurobiolaging.2016.10.027

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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