Article

Localized APP pathology in the hippocampus is sufficient to result in progressive disorganization of the timing of neuronal firing patterns

2022-10-25

Abstract excerpt

Deficits in spatial navigation are among the early symptoms in Alzheimer’s disease patients, consistent with the hippocampal formation as the site for spatial computations and disease onset. Although the correspondence between the early symptoms and brain regions that are affected early in the disease has been recognized, it is not clear whether progressive cognitive decline is solely caused by a spreading patholo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 412a9ecd-8187-5aae-849e-951aedc348a0
DOI: 10.1101/2022.10.24.513188

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Localized APP pathology in the hippocampus is sufficient to result in progressive disorganization of the timing of neuronal firing patternsDOI 10.1101/2022.10.24.513188Read

Disruption of the grid cell network in a mouse model of early Alzheimer’s diseaseSemantic proximity Read

Posterior parietal cortex oscillatory activity shapes persistent spatial memory impairments induced by soluble amyloid-β oligomersSemantic proximity Read

Early hippocampal hyperexcitability in PS2APP mice: role of mutant PS2 and APP.Semantic proximity Read

Aberrant medial entorhinal cortex dynamics link tau pathology to spatial memory impairmentSemantic proximity Read

Transsynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal network.Semantic proximity Read

Circuit-specific selective vulnerability in the DMN persists in the face of widespread amyloid burdenSemantic proximity Read

Early Electrophysiological Aberrations in the Hippocampus of the TgF344-AD Rat Model as a Potential Biomarker for Alzheimer’s Disease PrognosisSemantic proximity Read

Basal forebrain parvalbumin neuron dysfunction links network oscillation deficits to hippocampal pathology in Alzheimer’s diseaseSemantic proximity Read

Spatial coding defects of hippocampal neural ensemble calcium activities in the 3xTg-AD Alzheimer’s disease mouse modelSemantic proximity Read

Progressive excitability changes in the medial entorhinal cortex in the 3xTg mouse model of Alzheimer’s disease pathologySemantic proximity Read

Early-Onset Network Hyperexcitability in Presymptomatic Alzheimer’s Disease Transgenic Mice Is Suppressed by Passive Immunization with Anti-Human APP/Aβ Antibody and by mGluR5 BlockadeSemantic proximity Read

Spatial coding defects of hippocampal neural ensemble calcium activities in the triple-transgenic Alzheimer's disease mouse modelSemantic proximity Read