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Sumoylation: a regulatory protein modification in health and disease.

Annual review of biochemistry - 1 Jan 2013

Flotho Annette, Melchior Frauke

Abstract excerpt

Posttranslational modification with small ubiquitin-related modifier (SUMO) proteins is now established as one of the key regulatory protein modifications in eukaryotic cells. Hundreds of proteins involved in processes such as chromatin organization, transcription, DNA repair, macromolecular assembly, protein homeostasis, trafficking, and signal transduction are subject to reversible sumoylation. Hence, it is not...

Topics

Animals
Genetic Predisposition to Disease
Humans
Proteins
Signal Transduction
Small Ubiquitin-Related Modifier Proteins
Sumoylation

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 23746258
DOI: 10.1146/annurev-biochem-061909-093311

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