Article
E4orf4 induces PP2A- and Src-dependent cell death in Drosophila melanogaster and at the same time inhibits classic apoptosis pathways.
Proceedings of the National Academy of Sciences of the United States of America - 7 May 2013
Pechkovsky Antonina, Lahav Maoz, Bitman Eliya, Salzberg Adi, Kleinberger Tamar
Abstract excerpt
The adenovirus E4orf4 protein regulates the progression of viral infection, and when expressed alone in mammalian tissue culture cells it induces protein phosphatase 2A (PP2A)-B55- and Src-dependent cell death, which is more efficient in oncogene-transformed cells than in normal cells. This form of cell death is caspase-independent, although it interacts with classic caspase-dependent apoptosis....
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